A chemoprobe tracks its target

Stopping Ras in Its Tracks

Ras interacts with many downstream effectors that regulate complex cytoplasmic signaling networks. In this issue, Gupta et al. (2007) use mouse models of Ras-mediated tumorigenesis to show that the interaction of Ras with a single isoform of phosphatidylinositol 3-kinase (PI3K), called p110alpha (PIK3CA), is critical for tumor formation. This result will stimulate re-evaluation of pharmacologic...

Stopping MYC in its tracks

a transcriptional regulator that in order to function has to dimerize with a specific partner protein, MAX. The MYC-MAX dimer regulates the expression of thousands of genes involved in fundamental cellular processes including growth, proliferation, differentiation, biosynthesis, energy metabolism, and apoptosis [1-3]. The discovery that MYC becomes overexpressed as a result of chromosomal rearr...

Online consistency checking for AM-FM target tracks

We compute AM-FM models for infrared video frames depicting military targets immersed in structured clutter backgrounds. We show that independent correlation based detection processes can be implemented in the pixel and modulation domains and used to construct useful online track consistency checks that indicate when the detection process has been degraded due to nonstationary evolution of the ...

Detection of unresolved target tracks in infrared imagery

Using a probabilistic hypothesis density filter to confirm tracks in a multi- target environment

In this paper, we aim to perform scalable multi-target particle filter tracking. Previously, the authors presented an approach to track initiation and deletion which maintains an existence probability on each track, including a “search track” which represents the existence probability and state distribution of an unconfirmed track. This approach was seen to perform well even in cases of low det...